well, it can obvioulsy be done succesfully and on schedule. In what some consider the worst section, Savannah to St Simmons, i was behind the 145' Westport Fighting Irish. yep, 145' ... he wasn't afraid of running the ditch.
it all comes down to choices. it's much easier to run outside if the weather cooperates, but the ditch is feasible with a 6' draft. At this time of the year though, it can get nasty outside adn running the ditch is easier on the boat... winds were over 20 kts on many of the days and i heard quite a few sportfishes trying to get reports on conditions, many coming back in.
can't compare the gulf in summer with the carolinas in november.
What No Wake Zones? except for south florida, mostly from Boca Raton on down, there are very few NWZ in the ICW... There are few near marinas and docks in the carolinas but that amount to under 5% of the ICW. not a factor. Narrow channels? it's not that narrow... you just have to do your homework and pay attention. Miss a marker, or get to close to the edge and yes, you will get in trouble.
on the upside, it is a beautiful run. Nice scenery, always different. very enjoyable. Just like some people prefer the backroads to interstates...