Hi Brenda,
Sounds like you have a wonderful adventure planned. We're lived aboard for about 11 years, full time. We were aboard a 35' Luhrs for about 2 years and the rest of the time was aboard our 53' YF. Before purchasing the 53' we were actually looking for a 48'. We have never regretted the decision. As a matter-of-fact, if we had to do it all over again, we would have gone to the 58' YF. But at the time, 35' to 53' was a HUGE jump for us.
As far as cruising stuff...
I don't know how much boating experience you both have but if you're not too familiar with the rules of the road, I would suggest a power squadron course at the very least. Getting your USCG Captain's license would be very useful but you have to have a certain number of hours logged in before you can take the course. In all honesty, it won't really teach you how to physically handle your particular boat but the information learned is priceless.
If you are going to travel along the ICW and anchor out at night, I would suggest planning the night before - mileage you would like to cover, options (at least 2, preferably 3) as to where you would like to anchor. Sometimes recent shoaling, too many boats in the anchorage, wrong wind direction, etc. might prevent you from anchoring in your first choice. Therefore you want to give yourself plenty of time to make it to your next option. Have good cruising guides and charts aboard to make it easier. (I can suggest many for the Chesapeake Bay and the Caribbean).
Never leave port without your vacuum sealer. Keeps the moisture out of all your food (flour, rice, etc.)
Remove as much packaging as you can from stuff so you can minimize the trash onboard between ports.
Have a water maker if you plan to be away from civilization for extended periods.
If you're going to be traveling rather than staying put, you don't need nearly the clothes you might think. You're not going to be with the same people in the next port, right?
On the other hand, you'd be surprised what a small world the cruising community really is, so find yourself a practical way to write down people's names, boat names, how you met, etc. For example, even though I like to have things on my computer, it was inefficient to have this info stored there. Most of the time, people would pull into port, see our boat and hail us on the VHF. Who has time to boot the PC? I kept small, two ringed binders next to the radio with the cards sorted alphabetically by boat name. Within the first 5 or 6 months, we had well over 100 boat names. We are now in the thousands. It was not unusual to have someone call us on the VHF or SSB whom we hadn't seen in years. And I don't know about you, but my memory is great, it's just not very long! LOL
Anyhow, there's a bunch of other stuff but since I'm not sure what type of questions you would like answered I'll just stop for now.
Cheers,